Evidence of Interaction between PTPN22 and p53 codon 72 Polymorphisms on Susceptibility to Immune Related Diseases
نویسندگان
چکیده
منابع مشابه
Frequency of p53 Gene Codon 72 Polymorphisms in Women with Breast Cancer in Iran
Backgrounds and Aims: P53 gene is regarded important in pathogenesis of different cancers. Therefore, this study aimed to investigate the frequency of p53 gene codon 72 Arg/Pro polymorphism in women suffering from breast cancer. Materials and Methods: A total of 90 patients with breast cancer and 83 matched healthy control women participated in this case-control study. Genomic DNA was extrac...
متن کاملRelationship between p53 codon 72 polymorphism and susceptibility to sunburn and skin cancer.
Upregulation of p53 protein induces either growth arrest or apoptosis in response to cellular injury This is signaled from a highly conserved p53 domain between codons 64 and 92, where a functional polymorphism results in either a proline (p53-72P) or an arginine (p53-72R) at codon 72. Preliminary studies suggest that p53-72R may be a risk factor for cervical cancer and, consistent with this, p...
متن کاملP53 codon 11, 72, and 248 gene polymorphisms in endometriosis
OBJECTIVE Mutated p53 gene is related to the instability of cell growth and cell cycle progression. We aimed to evaluate the association between endometriosis and p53 codon 11, 72 and 248 gene polymorphisms. PATIENTS AND METHODS Women were divided into two groups: (1) moderate/severe endometriosis (n=148), and (2) non-endometriosis groups (n=150). P53 gene polymorphisms include codon11 Glu/Gl...
متن کاملAssociation between p53 codon 72 polymorphisms and clinical outcome of nasopharyngeal carcinoma.
We conducted a cohort study to investigate whether polymorphisms in p53 at codon 72 are associated with tumor response and survival time of advanced nasopharyngeal carcinoma (NPC) patients treated with radiotherapy. The study population included 127 subjects with NPC who were enrolled at Binzhou Medical University between September 2008 and December 2009. Cox proportional hazard regression was ...
متن کاملp53 codon 72 polymorphism and coronary artery disease: Evidence of interaction with ACP1
BACKGROUND Common biological features between cancer and atherosclerosis suggest possible association of p53 with atherosclerotic diseases, but data on such a relationship are controversial, suggesting interactions with other variables. Acid phosphatase locus 1 (ACPACP₁) is a polymorphic gene that controls the synthesis of an enzyme involved in important metabolic functions. Since ACPACP₁ is as...
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ژورنال
عنوان ژورنال: British Journal of Medicine and Medical Research
سال: 2013
ISSN: 2231-0614
DOI: 10.9734/bjmmr/2013/2888